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姓    名:
唐淳
性    别:
职    务:
研究员
职    称:
研究员
通讯地址:
武汉市武昌区小洪山西30号
邮政编码:
430071
电子邮件:
tanglab@wipm.ac.cn
电    话:
87197133

 简历:
 
  唐淳研究员,中国科学院博士生导师,美国马里兰大学生物化学博士。2003至2007年在美国国立卫生研究院(NIH)从事博士后研究,2008至2009年任美国密苏里大学生物化学系终生制助理教授(Tenure-track Assistant Professor),2009年底进入武汉物理与数学研究所,任研究员,中国科学院生物磁共振分析重点实验室主任。

  唐淳研究员长期致力于蛋白质动态结构与功能、蛋白质结构与功能的别构调节,以及蛋白质动态结构方法学的研究,在国内外生物核磁共振领域已有了较大的影响力。已经发表50余篇研究论文(3篇以第一作者发表于Nature),引用近2200多次。获得或申请专利7项。多次受邀在国内外学术会议上作特邀或口头报告,为Angew. Chem. Int. Ed., Biochemistry, J. Am. Chem. Soc., J. Mol. Biol., PLoS Biol., PLoS Comput. Biol., Proteins, J. Biomol. NMR等杂志审稿,担任Biophysics Reports杂志编委,担任湖北省晶体学会理事长,中国生物磁共振专业委员会副秘书长、中国分子生物物理学会专业委员会委员。

  相关连接:tanglab.org

 研究领域:
 

  生物大分子结构的动态变化的可视化技术研发

  重大疾病相关的蛋白质动态结构与功能调控研究

  逆转录病毒衣壳蛋白的组装和去组装研究

  炎症反应过程中蛋白质与RNA的结构与功能研究

  肺癌转移转录子的结构和功能调控研究

  老年细胞内垃圾清除的生物物理化学机制研究

 社会任职:
 

 获奖及荣誉:
 

 

 代表论著:
 

  48. Ding YH, Gong Z, Dong X, Liu K, Liu Z, Liu C, He SM, Dong MQ, Tang C. (2017). Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem, 292,1187

  47. Gong Z, Gu XH, Guo DC, Wang J, Tang C. (2017). Protein structural ensembles visualized by solvent paramagnetic relaxation enhancement. Angew Chem Int Ed, 56,1002-1006

  46. Zhang JR, Liu N, Chacho RA, Gong Z, Liu Z, Qin WM, Tang C, Tang Y, Zhou JH. (2016). Structural basis of nonribosomal pepetide macrocyclization in fungi. Nat Chem Biol, doi: 10.1038/nchembio.2202.

  45. Wang X, Feng J, Xue Y, Guan ZY, Zhang DL, Liu Z, Gong Z, Wang Q, Huang JB, Tang C, Zou TT, Yin P. (2016) Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex. Nature, 534,575-578.

  44. Fang J, Cheng J, Wang J, Zhang Q, Liu M, Gong R, Wang P, Zhang X, Feng Y, Lan W, Gong Z, Tang C, Wong J, Yang H, Cao C, Xu Y. (2016) Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition. Nature Communications, doi:10.1038/ncomms11197.

  43. Jiang WX, Dong X, Jiang J, Yang YH, Yang J, Lu Yb, Fang SH, Wei EQ, Tang C, and Zhang WP. (2016) Specific cell surface labeling of GPCRs using split GFP. Sci.Rep. , doi: 10.1038/srep20568.

  42. Liu Z and Tang C. (2016) Ensemble structure description of Lys63-linked diubiquitin. Data in Brief, doi:10.1016/j.dib.2016.02.003.

  41. Gong Z, Ding YH, Dong X, Liu N, Zhang EE, Dong MQ and Tang C. (2016) Visualizing the ensemble structures of protein complexes using chemical cross-linking coupled with mass spectrometry. Biophys.Rep. , doi:10.1007/s41048-015-0015-y.

  40. Liu Z, Gong Z, Dong X and Tang C. (2016) Transient protein-protein interactions visualized by solution NMR. BBA Proteins and Proteomics, 1864, 115-122. (invited review)

  39. Liu Z, Gong Z, Jiang WX, Yang J, Zhu WK, Guo DC, Zhang WP, Liu ML and Tang C. (2015) Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. eLife,4:e05767.

  38. Zhang XQ, Lu JT, Jiang WX, Lu YB, Wu M, Wei EQ, Zhang WP and Tang C. (2015) NAMPT inhibitor and metabolite protect mouse brain from cryoinjury through distinct mechanisms. Neuroscience, 291, 230-40.

  37. Gong Z, Charles DS and Tang C. (2015) Conjoined use of EM and NMR in RNA structure refinement. Plos One, 10, e0120445.

  36. Xing Q, Huang P, Yang J, Sun JQ, Gong Z, Dong X, Guo DC, Chen SM, Yang YH, Wang Y, Yang MH, Yi M, Ding YM, Liu ML, Zhang WP and Tang C. (2014) Visualizing an ultra-weak protein-protein interaction in phosphorylation signaling. Angew Chem Int Ed ,53, 11501-11505. (back cover)

  35. Wang Y, Tang C, Wang EK and Wang J. (2014) Polyubiquitin chain linkage topology selects the functions from the underlying binding landscape. Plos Comput Biol, 10.

  34. Zhang Z, Zhang TL, Wang SS, Gong Z, Tang C, Chen JY and Ding JP. (2014) Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5. eLife, doi:10.7554/eLife.02687.

  33. Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE and De Guzman RN. (2014) NMR model of prgI-sipD interaction and its implications in the needle-tip assembly of the salmonella type III secretion system. J Mol Biol 426, 2958-2969.

  32. Liu Z, Gong Z, Guo DC, Zhang WP and Tang C. (2014) Subtle dynamics of holo glutamine binding protein revealed with a rigid paramagnetic probe. Biochemistry-Us, 53, 1403-1409.

  31. Gu XH, Gong Z, Guo DC, Zhang WP and Tang C. (2014) A decadentate Gd(III)-coordinating paramagnetic cosolvent for protein relaxation enhancement measurement. J Biomol NMR, 58, 149-154.

  30. Coffman K, Yang B, Lu J, Tetlow AL, Pelliccio E, Lu S, Guo DC, Tang C, Dong MQ and Tamanoi F. (2014) Characterization of the Raptor/ 4E-BP1 Interaction by chemical cross- linking coupled with mass spectrometry analysis. J Biol Chem, 289, 4723-4734.

  29. Zhao B, Zhang M, Han X, Zhang XY, Xing Q, Dong X, Shi QJ, Huang P, Lu YB, Wei EQ, Xia Q, Zhang WP and Tang C. (2013) Cerebral ischemia is exacerbated by extracellular nicotinamide phosphoribosyltransferase via a non-enzymatic mechanism. Plos One, 8. 28. Li CG, Tang C and Liu ML. (2013) Protein dynamics elucidated by NMR technique. Protein Cell, 4, 726-730.

  27. Jiang B, Luo F, Ding YM, Sun P, Zhang X, Jiang L, Li CG, Mao XA, Yang DW, Tang C and Liu ML. (2013) NASR: an effective approach for simultaneous noise and artifact suppression in NMR spectroscopy. Anal Chem, 85, 2523-2528.

  26. Wang Y, Tang C, Wang EK and Wang J. (2012) Exploration of multi-state conformational dynamics and underlying global functional landscape of maltose binding protein. Plos Comput Biol,8.

  25. Liu Z, Zhang WP, Xing Q, Ren XF, Liu ML and Tang C. (2012) Noncovalent dimerization of ubiquitin. Angew Chem Int Ed, 51, 469-472.

  24. 刘主,唐淳. (2011) 顺磁弛豫增强技术与蛋白质瞬态结构. 波谱学杂志, 28, 301-316.

  23. Rathinavelan T, Tang C and De Guzman RN. (2011) Characterization of the interaction between the salmonella type III secretion system tip protein sipD and the needle protein prgI by paramagnetic relaxation enhancement. J Biol Chem, 286, 4922-4930.

  22. Yu DM, Volkov AN and Tang C. (2009) Characterizing dynamic protein-protein interactions using differentially scaled paramagnetic relaxation enhancement. J Am Chem Soc, 131, 17291-17297.

  Before 2009

  21. Tang C, Louis JM, Aniana A, Suh JY and Clore GM. (2008) Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease. Nature, 455, 693-696.

  20. Tang C, Ghirlando R and Clore GM. (2008) Visualization of transient ultra-weak protein self-association in solution using paramagnetic relaxation enhancement. J Am Chem Soc, 130, 4048-4056.

  19. Kim YC, Tang C, Clore GM and Hummer G. (2008) Replica exchange simulations of transient encounter complexes in protein-protein association. P Natl Acad Sci USA, 105, 12855-12860.

  18. Tang C, Schwieters CD and Clore GM. (2007) Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature 449, 1078-1082.

  17. Clore GM, Tang C and Iwahara J. (2007) Elucidating transient macromolecular interactions using paramagnetic relaxation enhancement. Curr Opin Struc Biol, 17, 603-616.

  16. Iwahara J, Tang C and Marius Clore G. (2007) Practical aspects of (1)H transverse paramagnetic relaxation enhancement measurements on macromolecules. Journal of magnetic resonance, 184, 185-195.

  15. Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF and Hill CP. (2007) Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. J Mol Biol, 373, 355-366.

  14. Suh JY, Tang C and Clore GM. (2007) Role of electrostatic interactions in transient encounter complexes in protein-protein association investigated by paramagnetic relaxation enhancement. J Am Chem Soc, 129, 12954-12955.

  13. Tang C, Iwahara J and Clore GM. (2006) Visualization of transient encounter complexes in protein-protein association. Nature, 444, 383-386.

  12. Tang C and Clore GM. (2006) A simple and reliable approach to docking protein-protein complexes from very sparse NOE-derived intermolecular distance restraints. J Biomol NMR, 36, 37-44.

  11. Tang C, Williams DC, Ghirlando R and Clore GM. (2005) Solution structure of enzyme IIA(Chitobiose) from the N,N '-diacetylchitobiose branch of the Escherichia coli phosphotransferase system. J Biol Chem 280, 11770-11780.

  10. Suh JY, Tang C, Cai ML and Clore GM. (2005) Visualization of the phosphorylated active site loop of the cytoplasmic B domain of the mannitol transporter IIMannitol of the Escherichia coli phosphotransferase system by NMR spectroscopy and residual dipolar couplings. J Mol Biol 353, 1129-1136.

  9. Tang C, Iwahara J and Clore G. (2005) Accurate determination of leucine and valine side-chain conformations using U-[N-15/C-13/H-2]/[H-1-(methine/methyl)-Leu/Val] isotope labeling, NOE pattern recognition, and methine C gamma-H gamma/C beta-H beta residual dipolar couplings: application to the 34-kDa enzyme IIA (Chitobiose). J Biomol NMR 33, 105-121.

  8. Tang C, Loeliger E, Luncsford P, Kinde I, Beckett, D and Summers MF. (2004) Entropic switch regulates myristate exposure in the HIV-1 matrix protein. P Natl Acad Sci USA 101, 517-522.

  7. Tang C, Loeliger E, Kinde I, Kyere S, Mayo K, Barklis E, Sun YN, Huang MJ and Summers MF. (2003) Antiviral inhibition of the HIV-1 capsid protein. J Mol Biol 327, 1013-1020.6. Gatanaga H, Suzuki Y, Tsang H, Yoshimura K, Kavlick MF, Nagashima K, Gorelick R. J, Mardy S, Tang C, Summers MF and Mitsuya H. (2002) Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors. J Biol Chem 277, 5952-5961.

  5. Tang C, Ndassa Y and Summers MF. (2002) Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein. Nat Struct Biol 9, 537-543. 4. Lin J, Blake M, Tang C, Zimmer D, Rustandi RR, Weber DJ and Carrier F. (2001) Inhibition of p53 transcriptional activity by the S100B calcium-binding protein. J Biol Chem, 276, 35037-35041.3. Gu T, Tang C and Xu ZD. (1999) Synthesis of C-60 nitroxide derivatives. Chinese Chem Lett, 10,95-96.

  2. Gu T, Tang, C and Xu ZD. (1999) Two methods to synthesize C-60 nitroxide derivatives. Fullerence Sci Techn, 7,297-303.

  1. Baldisseri DM, Rustandi RR, Zhang ZS, Tang C, Bair C. L, Landar A, Landar A, Zimmer DB and Weber DJ. (1999) Letter to the Editor: H-1, C-13 and N-15 NMR sequence-specific resonance assignments for rat apo-S100A1(alpha alpha).J Biomol NMR, 14,91-92 .

 承担科研项目情况:
 

 

  

 
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中国科学院武汉物理与数学研究所
地址:武汉市武昌小洪山 电话: 027-87199543